WebMar 1, 2004 · Thus, CD22-targeted delivery of CalichDMH is a potent and effective preclinical therapeutic strategy for BCLs. The strong antitumor profile of CMC-544 supports its clinical evaluation as a ... WebThe amounts of hP67.6-AcBut- CalichDMH in the various normal tissues and tumor (A431) xenografts are presented relative to the amount of conjugate in total blood (open circles, Y1 axis, % Blood ...
Treatment of Relapsed or Refractory Acute Lymphoblastic …
WebJul 1, 2004 · Cytotoxicity of hu3S193-CalichDMH was compared with toxicity of a control conjugate on monolayers of Le(y+) and Le(y-) carcinoma cells. Inhibition of tumor growth … WebDec 12, 2006 · CalichDMH is a derivative of gamma calicheamicin, a natural product of the enediyne class, that binds DNA in the minor groove and brings about double-strand DNA breaks leading to cellular apoptosis [6, 7]. The cytotoxic activity of CalichDMH is at least 10–100 fold more potent than conventional cytotoxic agents currently used in cancer ... gang violence and poverty
Antibody-targeted chemotherapy with CMC-544: A CD22-targeted ...
WebIn contrast, unconjugated CalichDMH, unconjugated G5/44, and an isotype-matched control conjugate, CMA-676, were ineffective against these BCL xenografts. Thus, CD22-targeted delivery of CalichDMH is a potent and effective preclinical therapeutic strategy for BCLs. The strong antitumor profile of CMC-544 supports its clinical evaluation as a ... WebFeb 18, 2008 · Hu3S193 in Treating Women With Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer - Full Text View. WebCalichDMH (Calicheamicin (CM)) Drug Class/Description Class: Calicheamicin Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner. gang victimization