Circrhobtb3
WebJun 1, 2024 · circRHOBTB3 regulated PTEN/Akt pathway by serving as the ceRNA of miR-23a-3p. Moreover, it has been widely recognized, as a tumor-suppressive gene, PTEN … WebMar 20, 2024 · CircRHOBTB3 interacted with the RNA-binding protein, IGF2BP3, to stabilize its expression in CC cells and is putatively transcriptionally regulated by NR1H4.
Circrhobtb3
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WebFeb 11, 2024 · Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer Jiaxin Chen, Yizheng Wu, +9 authors Zhangfa Song Biology, Medicine Theranostics 2024 TLDR Findings indicate that circRHOBTB3 exerts suppressive effects on CRC aggressiveness through the …
WebMar 21, 2024 · CircRHOBTB3 interacted with the RNA-binding protein, IGF2BP3, to stabilize its expression in CC cells and is putatively transcriptionally regulated by NR1H4. In conclusion, this novel NR1H4/circRHOBTB3/IGF2BP3 axis may provide new insights into CC pathogenesis. PMID: 36939994 WebJan 13, 2024 · Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth Taken together, this study revealed that circRHOBTB3 might …
WebMechanistically, circRHOBTB3 binds to HuR, which is a ubiquitously expressed and functional RNA-binding protein (RBP) in CRC development, and promotes β-Trcp1-mediated ubiquitination of HuR. Normally, HuR binds to the 3'UTR of target mRNAs to facilitate their stabilization, whereas the interaction between circRHOBTB3 and HuR degrades HuR to ... WebJun 1, 2024 · Results: We identified circRHOBTB3 which is markedly downregulated in CRC tissues and cell lines. Furthermore, lower circRHOBTB3 levels were significantly …
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WebJul 27, 2024 · CircRHOBTB3 interacted with the RNA-binding protein, IGF2BP3, to stabilize its expression in CC cells and is putatively transcriptionally regulated by NR1H4. bite block medicalWebJul 30, 2024 · Circular RNAs (circRNAs) have emerged as significant regulators in human cancers. We aimed to explore the functional role of circular RNA RHOBTB3 (circRHOBTB3) in ovarian cancer. The expression of circRHOBTB3 was detected by real-time quantitative PCR (RT-qPCR). bite block ortopediaWebIntroduction. Ischemic stroke and cerebral ischemia reperfusion injury can result in serious dysfunction of the brain, which leads to a high rate of morbidity, disability and mortality. 1 Various studies show that ischemia leads to a series of pathological events and activates signaling cascades to promote cell death. 2 Besides, a combination of many genetic and … bite block pedia 38fr w strapWebFigure Legend Snippet: CircRHOBTB3 is down-regulated in EOC. A Schematic illustration showing the circularization of RHOBTB3 exon 6 and exon 7 forming circRHOBTB3. B Relative expression of circRHOBTB3 in OC cell lines compared with IOSE-80 was measured by qRT-PCR. C The existence of circRHOBTB3 was validated by RT–PCR … bite block head and neck radiationWebApr 13, 2024 · Background Osteoarthritis (OA) is the most prevalent age-related disease in the world. Chondrocytes undergo an age-dependent decline in their proliferation and synthetic capacity, which is the main cause of OA development. However, the intrinsic mechanism of chondrocyte senescence is still unclear. This study aimed to investigate … dashi miso soup recipeWebCircRHOBTB3 was downregulated in ovarian cancer tissues and cells. RESULTS: Functionally, circRHOBTB3 overexpression could markedly suppress cell proliferation, metastasis and glycolysis, whereas the opposite results could be observed in the deletion of circRHOBTB3. Additionally, xenograft experiment also identified the above results. bite block in spanishWebing in diseases’ occurrence. CircRHOBTB3 has been reported to participate intimately in the progression of some cancers. Nevertheless, the mechanism by which circRHOBTB3 regulates tumorigenesis in epithelial ovarian cancer (EOC) remains ill-dened. The present study determined the expression pattern and bio-eects of circRHOBTB3 in EOC. bite block intubation