WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. WebCisplatin is both a substrate and inhibitor of OCT2 transport, and its accumulation and renal cytotoxicity has been demonstrated to be a consequence of the overexpression of OCT2 in human and rat proximal tubular epithelial cells (PTECs) ( Yonezawa et al., 2006 ).
Cisplatin: The first metal based anticancer drug - ScienceDirect
Webwww.ncbi.nlm.nih.gov WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ... bioshock mannequin
Role of membrane transportors in cisplatin induced …
WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … WebApr 30, 2015 · Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 … WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. bioshock male oc fanfiction