Cisplatin transporter

WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. WebCisplatin is both a substrate and inhibitor of OCT2 transport, and its accumulation and renal cytotoxicity has been demonstrated to be a consequence of the overexpression of OCT2 in human and rat proximal tubular epithelial cells (PTECs) ( Yonezawa et al., 2006 ).

Cisplatin: The first metal based anticancer drug - ScienceDirect

Webwww.ncbi.nlm.nih.gov WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ... bioshock mannequin https://sofiaxiv.com

Role of membrane transportors in cisplatin induced …

WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … WebApr 30, 2015 · Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 … WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. bioshock male oc fanfiction

The copper transporter Ctr1 contributes to cisplatin uptake by renal ...

Category:Significance of downregulation of renal organic cation transporter ...

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Cisplatin transporter

The roles of copper transporters in cisplatin resistance

WebSep 6, 2012 · Cisplatin is a potent cytostatic drug, whose use is limited by its severe acute and chronic nephro-, oto-, and peripheral neurotoxicity. For this reason, other platinum derivatives, such as carboplatin and oxaliplatin, with less toxicity but still with antitumoral action have been developed. WebApr 14, 2024 · Flavonoids are enriched in various vegetables, fruits, and herbal products, and some were reported to produce transporter-mediated DDIs. This study aimed to screen potential inhibitors of OCT2 from 96 flavonoids, assess the nephroprotective effects on cisplatin-induced kidney injury, and clarify the structure-activity relationships of ...

Cisplatin transporter

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WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL …

WebNov 15, 2024 · Magnesium co-administration decreases cisplatin-induced nephrotoxicity in the multiple cisplatin administration Life Sci. 2024 Nov 15;189:18-22. doi: 10.1016/j ... Expression of renal organic cation transporter 2 (rOct2) and multidrug and toxin extrusion protein 1 (rMate1), which are involved in CDDP transport, did not differ between the … WebThe direction of MATE1 transport is defined by the proton concentration gradient: when assayed in vitro at pH 7.4 or higher, MATE1 behaves as an uptake transporter, whereas …

WebEffects of siRNA-GLUT-1 and LY294002 on apoptosis and cell cycle in Hep-2 cells after treatment with cisplatinBefore the cisplatin treatment, the apoptotic rates of cells in the siRNA-GLUT-1 and LY294002 groups were increased markedly at 24 hours and 48 hours compared with the Hep-2 cell and siRNA-NC groups (P<0.05; Figure 2).The early … WebCisplatin triggers rapid degradation of Copper Transporter 1, reducing influx of cisplatin and increasing resistance to it. Explore the transporter in PDB ID 6m97 . Glutathione transferase (GST) P1-1 is a cisplatin-binding protein that can inactivate cisplatin.

WebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin …

WebAug 1, 2016 · Cisplatin Pazopanib Renal transporters OCT-2 Drug-drug interaction 1. Introduction Angiogenesis inhibitors represent a promising approach in the treatment of … dairy queen blizzard drawingWebJan 17, 2024 · System x c − is one among many amino acid transporters expressed in the plasma membrane of mammalian cells 1.This transporter is composed of xCT (SLC7A11), which is the substrate-specific ... bioshock location of helmetWebIn addition, cisplatin is the standard treatment of patients with non-small cell lung cancer (NSCLC) when druggable mutations are not present in the tumour 34. Hence, Pt drugs have not been... dairy queen blizzard birthday cakeWebDec 14, 2024 · Cisplatin (CDDP) is a chemotherapy drug commonly used in systemic treatment of germ cell tumors, including cancers of the ovaries, testes, and solid tumors of the head and neck 1. bioshock maintenance codeWebMar 9, 2024 · SLC11A2, also known as DMT1 (divalent metal transporter 1), is a metal transporter that has been shown to control the pool of cytoplasmic iron 32, therefore affecting the drug activation step... bioshock mcdonagh top floor codeWebThese transporters have a large binding site containing partially overlapping interaction domains for different substrates and are specifically distributed around the body. … bioshock more items downstairsWebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … dairy queen blizzard flavor of the month 2021