WebApr 13, 2024 · The FIDO2 (Fast IDentity Online) standard allows for replacing weak password-based authentication with strong hardware-based authentication using private and public key (asymmetric) cryptography. FIDO2 is the latest set of specifications from the FIDO Alliance. It enables using common devices to authenticate with online services on … The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The … See more Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding … See more Agonists Non-selective • Endogenous estrogens (e.g., estradiol, estrone, estriol, estetrol) • Natural estrogens (e.g., conjugated equine estrogens) • Synthetic estrogens (e.g., ethinylestradiol, diethylstilbestrol See more Coactivators of ER-α include: • SRC-1 • AIB1 – amplified in breast 1 • BCAS3 – Breast carcinoma amplified sequence 3 See more • McDonnell DP, Norris JD (May 2002). "Connections and regulation of the human estrogen receptor". Science. 296 (5573): 1642–1644. Bibcode:2002Sci...296.1642M. doi:10.1126/science.1071884. PMID 12040178. S2CID 30428909. • Simoncini T, Fornari L, Mannella … See more ERα plays a role in the physiological development and function of a variety of organ systems to varying degrees, including the reproductive, central nervous, skeletal, and cardiovascular systems. Accordingly, ERα is widely expressed throughout the … See more Estrogen insensitivity syndrome is a very rare condition characterized by a defective ERα that is insensitive to estrogens. The clinical presentation … See more Estrogen receptor alpha has been shown to interact with: • AKAP13 • AHR • BRCA1 • CAV1 • CCNC See more
PERK signaling through C/EBPδ contributes to ER stress-induced ...
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